Angelika Richter Selected Research

Dystonia (Limb Dystonia)

1/2021	Deep brain stimulation by optimized stimulators in a phenotypic model of dystonia: Effects of different frequencies.
1/2021	Mechanisms of pallidal deep brain stimulation: Alteration of cortico-striatal synaptic communication in a dystonia animal model.
1/2020	Striatal and cortical metabotropic glutamate 5 receptor expression and behavioral effects of the positive allosteric modulator CDPPB in a model of DYT1 dystonia.
9/2019	Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dtsz model.
3/2019	Optogenetic augmentation of the hypercholinergic endophenotype in DYT1 knock-in mice induced erratic hyperactive movements but not dystonia.
1/2019	Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia.
1/2017	Altered postnatal maturation of striatal GABAergic interneurons in a phenotypic animal model of dystonia.
1/2017	Sensorimotor tests unmask a phenotype in the DYT1 knock-in mouse model of dystonia.
1/2017	Alterations of M1 and M4 acetylcholine receptors in the genetically dystonic (dtsz) hamster and moderate antidystonic efficacy of M1 and M4 anticholinergics.
11/2016	The α2β3γ2 GABAA receptor preferring agonist NS11394 aggravates dystonia in the phenotypic dtsz model.

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Angelika Richter Research Topics

Disease

40	Dystonia (Limb Dystonia) 01/2021 - 05/2002
9	Dyskinesias (Dyskinesia) 01/2020 - 08/2002
7	Chorea (Rheumatic Chorea) 10/2005 - 11/2002
5	Movement Disorders (Movement Disorder) 01/2022 - 10/2004
5	Dystonia musculorum deformans type 1 01/2020 - 02/2011
3	Pain (Aches) 01/2019 - 01/2016
3	Parkinson Disease (Parkinson's Disease) 12/2017 - 06/2013
2	Bacterial Infections (Bacterial Infection) 06/2020 - 09/2003
1	Meningitis 01/2021
1	Bacterial Meningitis 01/2021
1	Infections 06/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2016
1	Necrosis 01/2016
1	Body Weight (Weight, Body) 01/2016
1	Peritonitis 01/2016
1	Retrograde Degeneration 01/2008

Drug/Important Bio-Agent (IBA)

9	gamma-Aminobutyric Acid (GABA)IBA 01/2017 - 05/2002
5	Cholinergic Agents (Cholinergics)IBA 03/2019 - 07/2006
4	Messenger RNA (mRNA)IBA 01/2020 - 01/2017
4	Proteins (Proteins, Gene)FDA Link 12/2017 - 12/2008
3	Glutamic Acid (Glutamate)FDA Link 01/2020 - 02/2011
3	BicucullineIBA 06/2010 - 05/2002
3	Pentylenetetrazole (Metrazol)IBA 06/2010 - 05/2002
3	MuscimolIBA 06/2010 - 05/2002
3	ParvalbuminsIBA 05/2007 - 09/2005
2	Anti-Infective Agents (Microbicides)IBA 06/2020 - 09/2003
2	3- cyano- N- (1,3- diphenyl- 1H- pyrazol- 5- yl)benzamideIBA 01/2020 - 09/2019
2	Levodopa (L Dopa)FDA LinkGeneric 09/2019 - 06/2013
2	Calcium Channels (Calcium Channel)IBA 01/2019 - 01/2018
2	BenzodiazepinesIBA 11/2016 - 05/2002
2	N- (6- Chloropyridin- 3- yl)- 3,4- difluorobenzamideIBA 01/2016 - 06/2013
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2014 - 01/2003
2	Pharmaceutical PreparationsIBA 10/2014 - 01/2008
2	Dopamine (Intropin)FDA LinkGeneric 08/2010 - 06/2004
2	2,3- dioxo- 6- nitro- 7- sulfamoylbenzo(f)quinoxaline (NBQX)IBA 06/2010 - 06/2007
2	GABA-A Receptor AntagonistsIBA 06/2010 - 05/2002
2	AcidsIBA 06/2010 - 06/2004
2	GABA-A Receptor AgonistsIBA 06/2010 - 05/2002
2	NNC 711 (NO 711)IBA 06/2010 - 10/2005
2	Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)IBA 05/2008 - 09/2003
2	Ro 61-8048IBA 05/2008 - 09/2003
2	GABA-A Receptors (GABA(A) Receptor)IBA 08/2007 - 05/2002
2	Sodium Channels (Sodium Channel)IBA 06/2004 - 12/2003
2	SpermineIBA 08/2003 - 01/2003
1	Ampicillin (Omnipen)FDA LinkGeneric 01/2021
1	EnrofloxacinIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric 01/2021
1	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2021
1	Doxycycline (Periostat)FDA LinkGeneric 01/2021
1	Oxygen (Dioxygen)IBA 06/2020
1	Metabotropic Glutamate 5 ReceptorIBA 01/2020
1	fenobamIBA 09/2019
1	AcetylcholinesteraseIBA 03/2019
1	Substance PIBA 03/2019
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019
1	SynucleinsIBA 12/2017
1	Small Interfering RNA (siRNA)IBA 12/2017
1	PolyethyleneimineIBA 12/2017
1	CationsIBA 01/2017
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2017
1	Trihexyphenidyl (Artane)FDA LinkGeneric 01/2017
1	ChloridesIBA 01/2017
1	Tropicamide FDA LinkGeneric 01/2017
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017
1	Clonazepam (Rivotril)FDA LinkGeneric 11/2016
1	3'- (5- (1- hydroxy- 1- methylethyl)benzoimidazol- 1- yl)biphenyl- 2- carbonitrileIBA 11/2016
1	Zolpidem (Ambien)FDA LinkGeneric 11/2016
1	alpha-SynucleinIBA 05/2016
1	Potassium Channels (Potassium Channel)IBA 01/2016
1	Anesthetics (Anesthetic Agents)IBA 01/2016
1	Hormones (Hormone)IBA 01/2016
1	Chloral HydrateIBA 01/2016
1	ezogabine (retigabine)IBA 01/2016
1	5- (alpha- methyl- 4- bromobenzylamino)phosphonomethyl- 1,4- dihydroquinoxaline- 2,3- dioneIBA 11/2014
1	(5,6-dimethoxyindan-2-yl)dipropylamineIBA 08/2010
1	GABA Plasma Membrane Transport ProteinsIBA 06/2010
1	AMPA Receptors (AMPA Receptor)IBA 06/2010
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 09/2009
1	NAD (NADH)IBA 02/2009
1	brivaracetamIBA 12/2008
1	Pyrrolidinones (Pyrrolidones)IBA 12/2008
1	SeletracetamIBA 12/2008
1	Levetiracetam (Keppra)FDA LinkGeneric 12/2008
1	LigandsIBA 12/2008
1	Oxidopamine (6 Hydroxydopamine)IBA 01/2008
1	NeurosteroidsIBA 08/2007
1	Acetates (Acetic Acid Esters)FDA Link 08/2007
1	Dehydroepiandrosterone (DHEA)IBA 08/2007
1	Pregnanolone (Allopregnanolone)IBA 08/2007
1	pregnenolone sulfateIBA 08/2007
1	tetrahydrodeoxycorticosteroneIBA 08/2007
1	Excitatory Amino Acid AntagonistsIBA 06/2007
1	RotenoneIBA 02/2007

Therapy/Procedure

5	Injections 01/2016 - 05/2002
4	Deep Brain Stimulation 01/2022 - 05/2010
3	Therapeutics 01/2019 - 06/2013
1	Cannula 03/2019
1	Drug Therapy (Chemotherapy) 06/2013
1	Intraperitoneal Injections 08/2007